Drug General Information
Drug ID	D09TAB
Former ID	DIB008584
Drug Name	PLX-3397
Synonyms	Fms/Kit/Flt-3-ITD inhibitor (cancer/inflammatory disease), Plexxikon
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Phase 3	[525099]
Company	Plexxikon Inc
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Mast/stem cell growth factor receptor	Target Info	Inhibitor	[550447]
	Macrophage colony-stimulating factor receptor	Target Info	Inhibitor	[550447]
	FL cytokine receptor	Target Info	Inhibitor	[550447]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Cytokine-cytokine receptor interaction
	Endocytosis
	PI3K-Akt signaling pathway
	Hematopoietic cell lineage
	Melanogenesis
	Pathways in cancer
	Acute myeloid leukemia
	Central carbon metabolism in cancerhsa04060:Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	Pathways in cancerhsa04060:Cytokine-cytokine receptor interaction
	Transcriptional misregulation in cancer
	Central carbon metabolism in cancer
NetPath Pathway	IL3 Signaling Pathway
	IL4 Signaling Pathway
	KitReceptor Signaling PathwayNetPath_22:Leptin Signaling Pathway
	RANKL Signaling Pathway
Pathway Interaction Database	C-MYB transcription factor network
	Signaling events mediated by Stem cell factor receptor (c-Kit)
Reactome	PIP3 activates AKT signaling
	Regulation of KIT signaling
	Constitutive Signaling by Aberrant PI3K in Cancer
	RAF/MAP kinase cascade
WikiPathways	Kit receptor signaling pathway
	Differentiation Pathway
	Signaling by SCF-KIT
	PIP3 activates AKT signaling
	Cardiac Progenitor Differentiation
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
References
Ref 525099	ClinicalTrials.gov (NCT02371369) PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS). U.S. National Institutes of Health.
Ref 550447	National Cancer Institute Drug Dictionary (drug id 659167).

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