Drug General Information
Drug ID	D09TXU
Former ID	DIB008763
Drug Name	DT-831j
Synonyms	DT-831j; Factor Xa antagonists, Daiichi Sankyo
Indication	Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Investigative	[531405], [531982]
Company	Daiichi Sankyo Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(C)(C)(Oc1ccc(NC(=O)c2[nH]c3c(c2)cc(cc3)Cl)c(NC(=O)c2s<br />c3c(n2)CCN(C3)C)c1)C(=O)O
Target and Pathway
Target(s)	Coagulation factor Xa	Target Info	Antagonist	[531405], [531982]
KEGG Pathway	Complement and coagulation cascades
PANTHER Pathway	Blood coagulation
Pathway Interaction Database	Beta2 integrin cell surface interactions
PathWhiz Pathway	Coagulation
Reactome	Extrinsic Pathway of Fibrin Clot Formation
	Intrinsic Pathway of Fibrin Clot Formation
	Common Pathway of Fibrin Clot Formation
	Gamma-carboxylation of protein precursors
	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
	Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways	Complement and Coagulation Cascades
	Human Complement System
	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
	Blood Clotting Cascade
	Formation of Fibrin Clot (Clotting Cascade)
References
Ref 531405	Venous thromboembolism in the patient with cancer: focus on burden of disease and benefits of thromboprophylaxis. Cancer. 2011 Apr 1;117(7):1334-49.
Ref 531982	Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7.
Ref 531405	Venous thromboembolism in the patient with cancer: focus on burden of disease and benefits of thromboprophylaxis. Cancer. 2011 Apr 1;117(7):1334-49.
Ref 531982	Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7.

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