Drug Information

Drug General Information
Drug ID
D09UQM
Former ID
DNC006812
Drug Name
1-(3,4-dichlorophenyl)-3-hydroxyurea
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528240]
Structure
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2D MOL

3D MOL
Formula
C7H6Cl2N2O2
Canonical SMILES
C1=CC(=C(C=C1NC(=O)NO)Cl)Cl
InChI
1S/C7H6Cl2N2O2/c8-5-2-1-4(3-6(5)9)10-7(12)11-13/h1-3,13H,(H2,10,11,12)
InChIKey
VKYZMAVGJARVPE-UHFFFAOYSA-N
PubChem Compound ID
97463
Target and Pathway
Target(s) Carbonic anhydrase Target Info Inhibitor [528240]
Carbonic anhydrase IV Target Info Inhibitor [528240]
Carbonic anhydrase IX Target Info Inhibitor [528240]
Carbonic anhydrase II Target Info Inhibitor [528240]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamationhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Pathway Interaction Database HIF-1-alpha transcription factor network
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 528240Bioorg Med Chem Lett. 2006 Aug 15;16(16):4316-20. Epub 2006 Jun 12.N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors.
Ref 528240Bioorg Med Chem Lett. 2006 Aug 15;16(16):4316-20. Epub 2006 Jun 12.N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors.

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