Drug Information

Drug General Information
Drug ID
D09VLE
Former ID
DNC008411
Drug Name
4,12,17-dehydroxyriccardin C
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529375]
Structure
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2D MOL

3D MOL
Formula
C28H24O
Canonical SMILES
C1CC2=CC(=CC=C2)OC3=CC=C(CCC4=CC=CC=C4C5=CC=C1C=C5)C=C3
InChI
1S/C28H24O/c1-2-7-28-24(5-1)15-10-22-13-18-26(19-14-22)29-27-6-3-4-23(20-27)9-8-21-11-16-25(28)17-12-21/h1-7,11-14,16-20H,8-10,15H2
InChIKey
VHGMCOKOKWHSEA-UHFFFAOYSA-N
PubChem Compound ID
24860516
Target and Pathway
Target(s) Oxysterols receptor LXR-alpha Target Info Inhibitor [529375]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear Receptors
References
Ref 529375Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.
Ref 529375Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.

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