Drug General Information
Drug ID	D09VWI
Former ID	DIB011115
Drug Name	BRX-005
Synonyms	Arimoclomol maleate; BRX-005; BRX-220; Bimoclomol derivatives, Biorex
Indication	Amyotrophic lateral sclerosis [ICD9: 335.2; ICD10:G12.2]		Discontinued in Phase 2	[534488]
Company	Biorex Research and Development Co
Structure		Download 2D MOL 3D MOL
Canonical SMILES	[n+]1(cc(/C(=N/OC[C@@H](CN2CCCCC2)O)/Cl)ccc1)[O-].C(=O)<br />(/C=C\C(=O)O)O
CAS Number	CAS 289893-26-1
Target and Pathway
Target(s)	Heat shock protein 70	Target Info	Modulator	[525882]
References
Ref 534488	Bimoclomol: a nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects. Nat Med. 1997 Oct;3(10):1150-4.
Ref 525882	Cardiovascular effects of BRX-005 comparison to bimoclomol. Life Sci. 2000 Aug 25;67(14):1783-9.

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