Drug Information

Drug General Information
Drug ID
D09WRI
Former ID
DIB010144
Drug Name
ELINAFIDE MESILATE
Synonyms
LU-79553; Elinafide mesilate < Prop INNM >; 2,2'-Propane-1,3-diylbis(iminoethylene)bis(2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione)dimethanesulfonate
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 2 [545863]
Structure
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2D MOL

3D MOL
Canonical SMILES
O=C1N(CCNCCCNCCN2C(=O)c3cccc4cccc(C2=O)c34)C(=O)c5cccc6<br />cccc1c56
InChI
1S/C31H28N4O4/c36-28-22-10-1-6-20-7-2-11-23(26(20)22)29(37)34(28)18-16-32-14-5-15-33-17-19-35-30(38)24-12-3-8-21-9-4-13-25(27(21)24)31(35)39/h1-4,6-13,32-33H,5,14-19H2
InChIKey
QUNOQBDEVTWCTA-UHFFFAOYSA-N
CAS Number
CAS 162706-37-8
Target and Pathway
Target(s) DNA topoisomerase II Target Info Inhibitor [525631], [551871]
References
Ref 545863Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005099)
Ref 525631Solution structure and dynamics of a complex between DNA and the antitumor bisnaphthalimide LU-79553: intercalated ring flipping on the millisecond time scale. Biochemistry. 1999 Nov 16;38(46):15104-15.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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