Drug Information

Drug General Information
Drug ID
D09WUP
Former ID
DNC008645
Drug Name
3,7-Bis(2-hydroxyethyl)icaritin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529676]
Structure
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2D MOL

3D MOL
Formula
C25H28O8
Canonical SMILES
CC(=CCC1=C(C=C(C2=C1OC(=C(C2=O)OCCO)C3=CC=C(C=C3)OC)O)O<br />CCO)C
InChI
1S/C25H28O8/c1-15(2)4-9-18-20(31-12-10-26)14-19(28)21-22(29)25(32-13-11-27)23(33-24(18)21)16-5-7-17(30-3)8-6-16/h4-8,14,26-28H,9-13H2,1-3H3
InChIKey
WTJGVHRGWYENBZ-UHFFFAOYSA-N
PubChem Compound ID
25058047
Target and Pathway
Target(s) CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Inhibitor [529676]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome cGMP effects
References
Ref 529676J Nat Prod. 2008 Sep;71(9):1513-7. Epub 2008 Sep 9.Potent inhibition of human phosphodiesterase-5 by icariin derivatives.
Ref 529676J Nat Prod. 2008 Sep;71(9):1513-7. Epub 2008 Sep 9.Potent inhibition of human phosphodiesterase-5 by icariin derivatives.

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