Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09YEQ
|
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| Former ID |
DIB020835
|
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| Drug Name |
Ro4491533
|
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| Synonyms |
Ro 4491533; Ro-4491533
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [541396] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C24H20F3N3O
|
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| InChI |
InChI=1S/C24H20F3N3O/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11H,12H2,1-3H3,(H,30,31)
|
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| InChIKey |
LYTVXCQQTLUEQR-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Metabotropic glutamate receptor3 | Target Info | Modulator (allosteric modulator) | [531231] | |
| Metabotropic glutamate receptor 2 | Target Info | Modulator (allosteric modulator) | [531703] | ||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Ionotropic glutamate receptor pathway | |||||
| Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Metabotropic glutamate receptor group II pathway | |||||
| References | |||||
| Ref 531231 | Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6969-74. | ||||
| Ref 531703 | Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression. J Neurogenet. 2011 Dec;25(4):152-66. | ||||
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