Drug General Information
Drug ID	D09YTH
Former ID	DIB012977
Drug Name	CPU-228
Synonyms	Dofetilide analog (cardiac failure), China Pharmaceutical University
Drug Type	Small molecular drug
Indication	Cardiac failure [ICD10:I50]		Investigative	[543871]
Company	China Pharmaceutical University
Structure		Download 2D MOL 3D MOL
Formula	C23H26N2O4S
Canonical SMILES	c12c(cccc1cccc2)OCCN(CCc1ccc(cc1)NS(=O)(=O)C)C(=O)C
PubChem Compound ID	10025495
Target and Pathway
Target(s)	Voltage-dependent L-type calcium channel subunit alpha-1C	Target Info	Modulator	[543866]
	Voltage-dependent P/Q-type calcium channel alpha-1A subunit	Target Info	Modulator	[543869]
	Voltage-dependent L-type calcium channel alpha-1D subunit	Target Info	Modulator	[543867]
	Voltage-dependent R-type calcium channel alpha-1E subunit	Target Info	Modulator	[543871]
	Voltage-dependent N-type calcium channel	Target Info	Modulator	[543870]
KEGG Pathway	MAPK signaling pathway
	Calcium signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Cardiac muscle contraction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Circadian entrainment
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Cholinergic synapse
	Serotonergic synapse
	GABAergic synapse
	Dopaminergic synapse
	Insulin secretion
	GnRH signaling pathway
	Oxytocin signaling pathway
	Type II diabetes mellitus
	Alzheimer's disease
	Amphetamine addiction
	Hypertrophic cardiomyopathy (HCM)
	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
	Dilated cardiomyopathyhsa04010:MAPK signaling pathway
	Synaptic vesicle cycle
	Long-term depression
	Taste transduction
	Morphine addiction
	Nicotine addictionhsa04010:MAPK signaling pathway
	Carbohydrate digestion and absorption
	Type II diabetes mellitushsa04010:MAPK signaling pathway
	Nicotine addiction
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Nicotinic acetylcholine receptor signaling pathway
	5HT2 type receptor mediated signaling pathway
	Beta1 adrenergic receptor signaling pathway
	Beta2 adrenergic receptor signaling pathway
	Oxytocin receptor mediated signaling pathway
	Nicotine pharmacodynamics pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group II pathway
	Thyrotropin-releasing hormone receptor signaling pathway
	Endogenous cannabinoid signaling
	GABA-B receptor II signalingP00003:Alzheimer disease-amyloid secretase pathway
	Oxytocin receptor mediated signaling pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Thyrotropin-releasing hormone receptor signaling pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	GABA-B receptor II signaling
PathWhiz Pathway	Muscle/Heart ContractionPW000619:Pancreas Function
Reactome	Adrenaline,noradrenaline inhibits insulin secretion
	NCAM1 interactions
	Regulation of insulin secretionR-HSA-112308:Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
	Regulation of insulin secretionR-HSA-400042:Adrenaline,noradrenaline inhibits insulin secretion
WikiPathways	Calcium Regulation in the Cardiac Cell
	Arrhythmogenic Right Ventricular Cardiomyopathy
	Alzheimers Disease
	NCAM signaling for neurite out-growth
	Integration of energy metabolism
	Nicotine Activity on Chromaffin CellsWP536:Calcium Regulation in the Cardiac Cell
	Synaptic Vesicle Pathway
	Type II diabetes mellitusWP536:Calcium Regulation in the Cardiac Cell
	Integration of energy metabolismWP536:Calcium Regulation in the Cardiac Cell
References
Ref 543871	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 534).
Ref 543866	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 529).
Ref 543867	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 530).
Ref 543869	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 532).
Ref 543870	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 533).
Ref 543871	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 534).

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