Drug Information

Drug General Information
Drug ID
D09YUS
Former ID
DIB003514
Drug Name
KRG-3332
Synonyms
Pivalic acid 3-[7-carbamoyl-5-[2(R)-[2-(2-ethoxyphenoxy)ethylamino]propyl]-1H-indol-1-yl]propyl ester hydrochloride
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Terminated [547722]
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Antagonist [534750]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK Signaling
References
Ref 547722Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018805)
Ref 534750The beta-adrenoceptor. Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 3):S146-53.

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