Drug Information

Drug General Information
Drug ID
D09ZLZ
Former ID
DIB014159
Drug Name
RAD-140
Synonyms
RAD-35010; Selective androgen receptor modulators (oral, sarcopenia/osteoporosis), Radius Health
Drug Type
Small molecular drug
Indication Osteoporosis [ICD9: 733.0, V07.4; ICD10:M80-M81, Z79.890] Investigative [552010]
Company
Radius Health Inc
Structure
Download
2D MOL

3D MOL
Formula
C20H16ClN5O2
Canonical SMILES
C(#N)c1c(c(c(cc1)N[C@H]([C@H](C)O)c1oc(nn1)c1ccc(cc1)C#<br />N)C)Cl
PubChem Compound ID
44200882
Target and Pathway
Target(s) Androgen receptor Target Info Modulator [552010]
KEGG Pathway Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 552010Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2010 Dec 2;2(2):124-9.
Ref 552010Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2010 Dec 2;2(2):124-9.

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