| Drug General Information |
| Drug ID |
D09ZOA
|
| Former ID |
DNC009764
|
| Drug Name |
2-(biphenyl-4-ylsulfonamido)-N-hydroxyacetamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C14H14N2O4S
|
| Canonical SMILES |
C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)NCC(=O)NO
|
| InChI |
1S/C14H14N2O4S/c17-14(16-18)10-15-21(19,20)13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-9,15,18H,10H2,(H,16,17)
|
| InChIKey |
NKGRTRASISLCCZ-UHFFFAOYSA-N
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| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Matrix metalloproteinase-14 |
Target Info |
Inhibitor |
[1]
|
|---|
| ADAM 17 |
Target Info |
Inhibitor |
[1]
|
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KEGG Pathway
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TNF signaling pathway
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GnRH signaling pathwayhsa04330:Notch signaling pathway
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Alzheimer's disease
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Epithelial cell signaling in Helicobacter pylori infection
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PANTHER Pathway
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Alzheimer disease-presenilin pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Alzheimer disease-presenilin pathway
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Notch signaling pathway
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Pathway Interaction Database
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HIF-2-alpha transcription factor network
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Signaling events mediated by focal adhesion kinaseerbb4_pathway:ErbB4 signaling events
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TNF receptor signaling pathway
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p75(NTR)-mediated signaling
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Reactome
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Collagen degradation
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Degradation of the extracellular matrix
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Activation of Matrix MetalloproteinasesR-HSA-1251985:Nuclear signaling by ERBB4
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Regulated proteolysis of p75NTR
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Activated NOTCH1 Transmits Signal to the Nucleus
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Constitutive Signaling by NOTCH1 PEST Domain Mutants
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Constitutive Signaling by NOTCH1 t(7
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M1580_K2555) Translocation Mutant
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Constitutive Signaling by NOTCH1 HD Domain Mutants
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
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TNF signaling
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Growth hormone receptor signaling
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WikiPathways
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Senescence and Autophagy in Cancer
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Activation of Matrix Metalloproteinases
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Degradation of collagen
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AGE/RAGE pathway
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Matrix MetalloproteinasesWP61:Notch Signaling Pathway
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Copper homeostasis
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Notch Signaling Pathway
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Growth hormone receptor signaling
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BDNF signaling pathway
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Alzheimers Disease
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Signalling by NGF
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Extrinsic Pathway for Apoptosis
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| References |
| REF 1 | J Med Chem. 2010 Mar 25;53(6):2622-35.Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models. |
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