Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09ZVC
|
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| Former ID |
DIB010369
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| Drug Name |
Begacestat
|
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| Synonyms |
GSI-953; PF-05212362; PF-5212362; WAY-201953; WAY-210953
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| Drug Type |
Small molecular drug
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| Company |
Wyeth
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| Structure |
|
Download2D MOL |
|||
| Formula |
C9H8ClF6NO3S2
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| InChI |
InChI=1S/C9H8ClF6NO3S2/c10-5-1-2-6(21-5)22(19,20)17-4(3-18)7(8(11,12)13)9(14,15)16/h1-2,4,7,17-18H,3H2/t4-/m1/s1
|
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| InChIKey |
PSXOKXJMVRSARX-SCSAIBSYSA-N
|
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| CAS Number |
CAS 769169-27-9
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Gamma-secretase | Target Info | Modulator | [530308] | |
| KEGG Pathway | Notch signaling pathway | ||||
| Alzheimer's disease | |||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Regulated proteolysis of p75NTR | |||||
| NRIF signals cell death from the nucleus | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| NOTCH2 Activation and Transmission of Signal to the Nucleus | |||||
| EPH-ephrin mediated repulsion of cells | |||||
| References | |||||
| Ref 530308 | Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. | ||||
| Ref 542009 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6979). | ||||
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