Drug Information

Drug General Information
Drug ID
D0A0KP
Former ID
DIB021256
Drug Name
zinterol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540404]
Structure
Download
2D MOL
Formula
C19H26N2O4S
InChI
InChI=1S/C19H26N2O4S/c1-19(2,12-14-7-5-4-6-8-14)20-13-18(23)15-9-10-17(22)16(11-15)21-26(3,24)25/h4-11,18,20-23H,12-13H2,1-3H3
InChIKey
XJBCFFLVLOPYBV-UHFFFAOYSA-N
PubChem Compound ID
37990
PubChem Substance ID
5757686, 7980908, 8175280, 12015574, 14829239, 34679218, 47217425, 47440939, 50064736, 57312137, 79624408, 90444652, 104328013, 117631926, 123099874, 123105660, 125413957, 126648866, 129695911, 131312394, 135049605, 137120083, 162224533, 164196663, 178100460, 179150395, 184823474, 223704934, 226490978
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [530999]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540404(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3466).
Ref 530999The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors. Br J Pharmacol. 2010 Jul;160(5):1048-61.

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