Drug Information

Drug General Information
Drug ID
D0A0MJ
Former ID
DIB001740
Drug Name
Nerve growth factor
Synonyms
Neuleze; Nerve growth factor (recombinant); RhNGF, Genentech; NGF-beta, Genentech; Nerve growth factor (recombinant), Genentech; Nerve growth factor, Mitsubishi/Dompe/Fidia
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Terminated [544700]
Company
Genentech Inc
Target and Pathway
Target(s) Beta-nerve growth factor Target Info Modulator [556264]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Pathway Interaction Database SHP2 signaling
p75(NTR)-mediated signaling
Neurotrophic factor-mediated Trk receptor signaling
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome Frs2-mediated activation
ARMS-mediated activation
NRAGE signals death through JNK
p75NTR negatively regulates cell cycle via SC1
PI3K/AKT activation
NADE modulates death signalling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation
WikiPathways SIDS Susceptibility Pathways
MAPK Signaling Pathway
BDNF signaling pathway
Signalling by NGF
NGF signalling via TRKA from the plasma membrane
References
Ref 544700Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000658)
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.