Drug Information

Drug General Information
Drug ID
D0A1NU
Former ID
DCL001101
Drug Name
ABT-279
Synonyms
LS-193221
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Discontinued in Phase 1 [548377]
Company
Abbott Lab
Structure
Download
2D MOL

3D MOL
Formula
C21H25N5O3
Canonical SMILES
CC1(CCN(CC1)C2=NC=CC(=C2)C(=O)O)NCC(=O)N3C(CCC3C#N)C#C
InChI
1S/C21H25N5O3/c1-3-16-4-5-17(13-22)26(16)19(27)14-24-21(2)7-10-25(11-8-21)18-12-15(20(28)29)6-9-23-18/h1,6,9,12,16-17,24H,4-5,7-8,10-11,14H2,2H3,(H,28,29)/t16-,17-/m0/s1
InChIKey
FIMRNLAKAARHPD-IRXDYDNUSA-N
PubChem Compound ID
16049769
PubChem Substance ID
28681064, 29614430, 46513101, 50076453, 103500878, 135692874, 137041622, 141495455, 163642522, 198960706, 226945979, 243931988, 251962930, 252214645
Target and Pathway
Target(s) Dipeptidyl peptidase IV Target Info Inhibitor [537022]
KEGG Pathway Protein digestion and absorption
NetPath Pathway IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
References
Ref 548377Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025075)
Ref 537022Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87.

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