Drug Information

Drug General Information
Drug ID
D0A1YQ
Former ID
DNC001296
Drug Name
SB216763
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542924]
Structure
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2D MOL

3D MOL
Formula
C19H12Cl2N2O2
InChI
InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
InChIKey
JCSGFHVFHSKIJH-UHFFFAOYSA-N
CAS Number
CAS 280744-09-4
PubChem Compound ID
176158
PubChem Substance ID
7343520, 10258353, 11109049, 11111799, 11114153, 14804046, 17405492, 24278616, 33499834, 47425384, 49674819, 50069836, 50104912, 50104913, 53778040, 53788992, 57395289, 68529953, 76969976, 85231225, 85789038, 90341064, 91746567, 92304118, 99436968, 103321785, 104425367, 110522903, 121361674, 124659174, 124756979, 124801217, 124881439, 124881440, 125163784, 125335564, 126666960, 128256156, 131308731, 131480748, 134341362, 134964391, 135154100, 135314161, 135685334, 135685335, 135685354, 135697689, 136340311, 136367277
Target and Pathway
Target(s) Glycogen synthase kinase-3 Target Info Inhibitor [537174], [537183], [537419]
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Insulin/IGF pathway-protein kinase B signaling cascade
PDGF signaling pathway
Ras Pathway
Pathway Interaction Database Degradation of beta catenin
Canonical Wnt signaling pathway
FOXM1 transcription factor network
Class I PI3K signaling events mediated by Akt
Reactome AKT phosphorylates targets in the cytosol
XBP1(S) activates chaperone genes
Constitutive Signaling by AKT1 E17K in Cancer
References
Ref 542924(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8015).
Ref 537174The ceiling effect of pharmacological postconditioning with the phytoestrogen genistein is reversed by the GSK3beta inhibitor SB 216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione] through mitochondrial ATP-dependent potassium channel opening. J Pharmacol Exp Ther. 2009 Jun;329(3):1134-41. Epub 2009 Mar 24.
Ref 537183Cocaine-induced hyperactivity and sensitization are dependent on GSK3. Neuropharmacology. 2009 Jun;56(8):1116-23. Epub 2009 Mar 27.
Ref 537419Intracellular protein phosphorylation in eosinophils and the functional relevance in cytokine production. Int Arch Allergy Immunol. 2009;149 Suppl 1:45-50. Epub 2009 Jun 3.

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