Drug Information

Drug General Information
Drug ID
D0A2KT
Former ID
DNC000069
Drug Name
4-DAMP
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540072]
Structure
Download
2D MOL

3D MOL
Formula
C21H26NO2+
InChI
InChI=1S/C21H26NO2/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19-20H,13-16H2,1-2H3/q+1
InChIKey
HYJRTXSYDAFGJK-UHFFFAOYSA-N
CAS Number
CAS 131614-02-3
PubChem Compound ID
1734
PubChem Substance ID
7436401, 11111027, 11113525, 24520015, 26756601, 29220936, 29459607, 47810980, 50065250, 50104431, 57321005, 79091531, 85229918, 90341358, 103136185, 103420255, 104061739, 104095321, 104298569, 117554815, 124749690, 124879811, 124879812, 125698531, 127995583, 128131044, 135066302, 135649797, 135687935, 162727089, 163426049, 179235691, 228815795
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M3 Target Info Antagonist [535437], [537414]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretion
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Gastric Acid Production
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540072(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 307).
Ref 535437The effects of the antagonists of muscarinic acetylcholine receptor subtypes in rat brain on urinary bladder contraction. Nippon Hinyokika Gakkai Zasshi. 2002 Mar;93(3):427-34.
Ref 537414An increase in intracelluar free calcium ions modulated by cholinergic receptors in rat facial nucleus. Chin Med J (Engl). 2009 May 5;122(9):1049-55.

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