Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0A2NK
|
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| Former ID |
DNC004870
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| Drug Name |
PYRIPYROPENE A
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C31H35NO10
|
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| Canonical SMILES |
CC(=O)OCC1(C(CCC2(C1C=C(C3(C2C(=C4C(=CC(OC4=O)C5=CN=CC=<br />C5)O3)O)C)OC(=O)C)C)OC(=O)C)C
|
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| InChI |
1S/C31H35NO10/c1-16(33)38-15-30(5)22-13-24(40-18(3)35)31(6)27(29(22,4)10-9-23(30)39-17(2)34)26(36)25-21(42-31)12-20(41-28(25)37)19-8-7-11-32-14-19/h7-8,11-14,20,22-23,27,36H,9-10,15H2,1-6H3
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| InChIKey |
APXYGOOSELMEEZ-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Liver carboxylesterase | Target Info | Inhibitor | [2] | |
| mRNA of human acyl CoA cholesterol acyl-transferase-2 | Target Info | Inhibitor | [1] | ||
| KEGG Pathway | Drug metabolism - other enzymes | ||||
| Metabolic pathwayshsa00100:Steroid biosynthesis | |||||
| PANTHER Pathway | Androgen/estrogene/progesterone biosynthesis | ||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| WikiPathways | NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Heroin metabolism | |||||
| Irinotecan Pathway | |||||
| Fluoropyrimidine Activity | |||||
| Phase I biotransformations, non P450 | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2005 Jan 17;15(2):385-8.Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors. | ||||
| REF 2 | Bioorg Med Chem Lett. 2004 Aug 16;14(16):4277-80.Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas. | ||||
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