Drug General Information
Drug ID	D0A2UV
Former ID	DCL001030
Drug Name	Ustekinumab
Synonyms	Stelara (TN)
Drug Type	Antibody
Indication	Moderate-to-severe plaque psoriasis [ICD9: 696; ICD10:L40]		Approved	[530677], [541942]
	Psoriasis [ICD9: 696; ICD10:L40]		Phase 3	[530677], [541942]
	Crohn's disease; Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51]		Phase 2/3	[530677], [541942]
Company	Centocor Ortho Biotech
Structure		Download 2D MOL 3D MOL
Formula	C14H18Cl3N5O2
PubChem Compound ID	121750
SuperDrug ATC ID	L04AC05
Target and Pathway
Target(s)	Interleukin-23 ligand	Target Info		[530677], [536371], [537117]
	Interleukin-12	Target Info		[530677], [536371], [537117]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Toll-like receptor signaling pathway
	RIG-I-like receptor signaling pathway
	Jak-STAT signaling pathway
	Type I diabetes mellitus
	Pertussis
	Legionellosis
	Leishmaniasis
	Chagas disease (American trypanosomiasis)
	African trypanosomiasis
	Malaria
	Toxoplasmosis
	Amoebiasis
	Tuberculosis
	Measles
	Influenza A
	Herpes simplex infection
	Inflammatory bowel disease (IBD)
	Allograft rejectionhsa04060:Cytokine-cytokine receptor interaction
	Allograft rejection
Pathway Interaction Database	IL27-mediated signaling events
	IL12-mediated signaling events
WikiPathways	Toll-like receptor signaling pathway
	Aryl Hydrocarbon Receptor Pathway
	Allograft Rejection
	Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
	Regulation of toll-like receptor signaling pathway
References
Ref 530677	Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
Ref 541942	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6885).
Ref 530677	Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
Ref 536371	Emerging drugs to treat Crohn's disease. Expert Opin Emerg Drugs. 2007 Mar;12(1):49-59.
Ref 537117	Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63.

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