Drug Information

Drug General Information
Drug ID
D0A4EA
Former ID
DNC010898
Drug Name
OLEIC ACID
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538637]
Structure
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2D MOL

3D MOL
Formula
C18H34O2
InChI
InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-
InChIKey
ZQPPMHVWECSIRJ-KTKRTIGZSA-N
CAS Number
CAS 112-80-1
PubChem Compound ID
445639
PubChem Substance ID
3978, 75221, 584561, 607054, 819801, 820852, 823248, 841649, 3140740, 4265936, 7849374, 7889573, 7889575, 8136926, 8144974, 10299740, 10504339, 11528277, 11532519, 14750979, 17388831, 24278605, 24856748, 24862437, 24886786, 24897936, 24897941, 24897944, 24897946, 24901337, 24901338, 26708080, 26732603, 26752911, 26759285, 29204451, 36888286, 46391972, 46392022, 46392136, 46393429, 48185141, 48417325, 48423867, 48425443, 49854224, 53789356, 56311729, 56314553, 56365484
Target and Pathway
Target(s) Fatty acid-binding protein, adipocyte Target Info Inhibitor [530916]
Fatty acid-binding protein, liver Target Info Inhibitor [529520]
KEGG Pathway PPAR signaling pathwayhsa03320:PPAR signaling pathway
Fat digestion and absorption
NetPath Pathway TCR Signaling Pathway
Pathway Interaction Database AP-1 transcription factor network
Reactome Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
Transcriptional regulation of white adipocyte differentiationR-HSA-163560:Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
WikiPathways Lipid digestion, mobilization, and transport
Transcriptional Regulation of White Adipocyte DifferentiationWP2882:Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Selenium Metabolism and Selenoproteins
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
References
Ref 538637(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1054).
Ref 529520J Med Chem. 2008 Jul 10;51(13):3755-64. Epub 2008 Jun 6.Characterization of the drug binding specificity of rat liver fatty acid binding protein.
Ref 530916Bioorg Med Chem Lett. 2010 Jun 15;20(12):3675-9. Epub 2010 Apr 24.Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening.

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