Drug Information

Drug General Information
Drug ID
D0A4HS
Former ID
DNC009808
Drug Name
4-methoxyphenylboronic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530086]
Structure
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2D MOL

3D MOL
Formula
C7H9BO3
Canonical SMILES
B(C1=CC=C(C=C1)OC)(O)O
InChI
1S/C7H9BO3/c1-11-7-4-2-6(3-5-7)8(9)10/h2-5,9-10H,1H3
InChIKey
VOAAEKKFGLPLLU-UHFFFAOYSA-N
PubChem Compound ID
201262
Target and Pathway
Target(s) Carbonic anhydrase Target Info Inhibitor [530086]
Fatty-acid amide hydrolase Target Info Inhibitor [529790]
Carbonic anhydrase I Target Info Inhibitor [530086]
Carbonic anhydrase II Target Info Inhibitor [530086]
BioCyc Pathway Anandamide degradation
KEGG Pathway Retrograde endocannabinoid signalinghsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Anandamide degradation
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Gastric Acid Production
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 530086Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Ref 529790J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
Ref 530086Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.

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