Drug General Information
Drug ID	D0A5XB
Former ID	DNC004642
Drug Name	Sulfamic acid benzo[1,3]dioxol-2-ylmethyl ester
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527479]
Structure		Download 2D MOL 3D MOL
Formula	C8H9NO5S
Canonical SMILES	C1=CC=C2C(=C1)OC(O2)COS(=O)(=O)N
InChI	1S/C8H9NO5S/c9-15(10,11)12-5-8-13-6-3-1-2-4-7(6)14-8/h1-4,8H,5H2,(H2,9,10,11)
InChIKey	UAXDMVNWVLYKAY-UHFFFAOYSA-N
PubChem Compound ID	11264735
Target and Pathway
Target(s)	Carbonic anhydrase II	Target Info	Inhibitor	[527479]
KEGG Pathway	Nitrogen metabolism
	Proximal tubule bicarbonate reclamation
	Collecting duct acid secretion
	Gastric acid secretion
	Pancreatic secretion
	Bile secretion
NetPath Pathway	IL4 Signaling Pathway
	EGFR1 Signaling Pathway
Reactome	Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Reversible hydration of carbon dioxide
WikiPathways	Reversible Hydration of Carbon Dioxide
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 527479	J Med Chem. 2005 Mar 24;48(6):1941-7.Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform.
Ref 527479	J Med Chem. 2005 Mar 24;48(6):1941-7.Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform.

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