Drug General Information
Drug ID
D0A8JP
Former ID
DNC008509
Drug Name
PARABEN
Indication Discovery agent Phase 3 [524059]
Structure
Download
2D MOL

3D MOL

Target and Pathway
Target(s) Carbonic anhydrase XIV Target Info Inhibitor [530751]
Carbonic anhydrase VI Target Info Inhibitor [530751]
Carbonic anhydrase IX Target Info Inhibitor [530751]
Carbonic anhydrase XII Target Info Inhibitor [530751]
Carbonic anhydrase II Target Info Inhibitor [530751]
Carbonic anhydrase Target Info Inhibitor [530751]
Carbonic anhydrase IV Target Info Inhibitor [530751]
Carbonic anhydrase I Target Info Inhibitor [530751]
KEGG Pathway Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretionhsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamationhsa00910:Nitrogen metabolism
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_16:IL4 Signaling Pathway
EGFR1 Signaling Pathway
Pathway Interaction Database HIF-1-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network
PathWhiz Pathway Gastric Acid Production
Reactome Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway
Reversible Hydration of Carbon Dioxide
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 524059ClinicalTrials.gov (NCT01688479) Trial Comparing Calendula Officinalis With Aqueous Cream "Essex" to Treat Skin Reactions From Radiotherapy of Breast Cancer. U.S. National Institutes of Health.
Ref 530751Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.

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