Drug General Information
Drug ID	D0AQ3H
Former ID	DIB002474
Drug Name	PF-610355
Synonyms	PF-00610355; Beta 2 adrenoceptor agonist (asthma), Pfizer
Indication	Asthma; Chronic obstructive pulmonary disease [ICD9: 490-492, 493, 494-496; ICD10:J40-J44, J47, J45]		Discontinued in Phase 2	[548443]
Company	Pfizer Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(cccc(c1)CC(=O)NCc1cc(ccc1)c1ccc(cc1)O)CC(NC[C@@H](c1<br />ccc(c(c1)NS(=O)(=O)C)O)O)(C)C
Target and Pathway
Target(s)	Beta-2 adrenergic receptor	Target Info	Agonist	[531136]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Adrenergic signaling in cardiomyocytes
	Salivary secretion
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database	Arf6 trafficking events
	Arf6 signaling events
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Vitamin D Receptor Pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 548443	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025582)
Ref 531136	Inhalation by design: novel ultra-long-acting beta(2)-adrenoreceptor agonists for inhaled once-daily treatment of asthma and chronic obstructive pulmonary disease that utilize a sulfonamide agonist headgroup. J Med Chem. 2010 Sep 23;53(18):6640-52.

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