Drug General Information
Drug ID	D0B0TO
Former ID	DIB009327
Drug Name	L-768277
Synonyms	L-766112
Indication	Hyperthermia [ICD10:T68]		Terminated	[546606]
Company	Merck Sharp & Dohme Research Laboratories
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c12n(c(c(s1)c1ccc(S(=O)(=O)C)cc1)c1ccccc1)ncn2
Target and Pathway
Target(s)	Prostaglandin G/H synthase 2	Target Info	Modulator	[551650]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	C20 prostanoid biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	NF-kappa B signaling pathway
	VEGF signaling pathway
	TNF signaling pathway
	Retrograde endocannabinoid signaling
	Serotonergic synapse
	Ovarian steroidogenesis
	Oxytocin signaling pathway
	Regulation of lipolysis in adipocytes
	Leishmaniasis
	Pathways in cancer
	Chemical carcinogenesis
	MicroRNAs in cancer
	Small cell lung cancer
NetPath Pathway	IL1 Signaling Pathway
	TSH Signaling Pathway
	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	IL5 Signaling Pathway
PANTHER Pathway	Endothelin signaling pathway
	Inflammation mediated by chemokine and cytokine signaling pathway
	Toll receptor signaling pathway
	CCKR signaling map ST
Pathway Interaction Database	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	S1P1 pathway
	C-MYB transcription factor network
	Signaling mediated by p38-alpha and p38-beta
	Calcium signaling in the CD4+ TCR pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Prostaglandin Synthesis and Regulation
	Arachidonic acid metabolism
	Aryl Hydrocarbon Receptor
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 546606	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009152)
Ref 551650	Characterization of the in vitro oxidative metabolites of the COX-2 selective inhibitor L-766,112. Bioorganic & Medicinal Chemistry Letters Volume 7, Issue 1, 7 January 1997, Pages 53-56.

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