Drug Information

Drug General Information
Drug ID
D0B1SG
Former ID
DIB011508
Drug Name
BMS-813160
Synonyms
BMS-585059; CCR2/CCR5 chemokine antagonist (immune disorders, cardiovascular disorders), BMS; CCR2/CCR5 dual antagonist (cardiovascular disease), Bristol-Myers Squibb; CCR2/CCR5 dual antagonist (immunology), Bristol-Myers Squibb
Indication Diabetic nephropathy [ICD9: 250.4; ICD10:E11.21] Phase 2 [524165]
Company
Bristol-myers squibb
Structure
Download
2D MOL

3D MOL
Canonical SMILES
CC(C)(N[C@H]1C[C@H]([C@@H](N2CC[C@@H](C2=O)Nc2ncnc3cc(C<br />(C)(C)C)nn23)CC1)NC(=O)C)C
Target and Pathway
Target(s) C-C chemokine receptor type 2 Target Info Modulator [531630]
C-C chemokinereceptor type 5 Target Info Modulator [531630]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathwayhsa04060:Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Toxoplasmosis
Viral carcinogenesis
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling PathwayNetPath_24:TSLP Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database IL12-mediated signaling events
Reactome Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling eventsR-HSA-173107:Binding and entry of HIV virion
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Defensins
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP69:TCR Signaling Pathway
HIV Life Cycle
GPCR downstream signaling
GPCRs, Other
References
Ref 524165ClinicalTrials.gov (NCT01752985) Study to Evaluate the Effects of BMS-813160 on Protein Loss in the Urine of Subjects With Type 2 Diabetes and Diabetic Kidney Disease. U.S. National Institutes of Health.
Ref 531630A dual CCR2/CCR5 chemokine antagonist, BMS-813160. Expert Opin Ther Pat. 2011 Dec;21(12):1919-24.

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