Drug General Information
Drug ID
D0B4JS
Former ID
DNC008482
Drug Name
1-(1,3-diphenylpropylidene)thiosemicarbazide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529432]
Structure
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2D MOL

3D MOL

Formula
C16H17N3S
Canonical SMILES
C1=CC=C(C=C1)CCC(=NNC(=S)N)C2=CC=CC=C2
InChI
1S/C16H17N3S/c17-16(20)19-18-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-10H,11-12H2,(H3,17,19,20)/b18-15-
InChIKey
AEHHXKHHRMBYLD-SDXDJHTJSA-N
PubChem Compound ID
Target and Pathway
Target(s) Cathepsin L Target Info Inhibitor [529432]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritis
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 529432Bioorg Med Chem Lett. 2008 May 1;18(9):2883-5. Epub 2008 Apr 8.Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB.
Ref 529432Bioorg Med Chem Lett. 2008 May 1;18(9):2883-5. Epub 2008 Apr 8.Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB.

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