Drug Information

Drug General Information
Drug ID
D0B4VE
Former ID
DNC000651
Drug Name
Flavanone
Drug Type
Small molecular drug
Indication Discovery agent Phase 1 [522793], [540674]
Structure
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2D MOL

3D MOL
Formula
C15H12O2
InChI
InChI=1S/C15H12O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-9,15H,10H2
InChIKey
ZONYXWQDUYMKFB-UHFFFAOYSA-N
CAS Number
CAS 487-26-3
PubChem Compound ID
10251
PubChem Substance ID
4028, 102205, 619227, 3134927, 4512170, 8138274, 8157393, 10523909, 10589599, 11341995, 11362178, 11362915, 11365477, 11368039, 11371267, 11375249, 11376201, 11408604, 11483925, 11487580, 11488021, 11489990, 11493460, 11493895, 14717855, 15043641, 24295177, 24846563, 26613018, 26679643, 26749819, 29204140, 29228771, 47217216, 47515755, 47885852, 48110894, 48259673, 48421824, 49969977, 50107717, 50107718, 52951290, 53787071, 56367296, 57326076, 85209501, 85730926, 85789144, 85789390
ChEBI ID
ChEBI:5070
Target and Pathway
Target(s) Corticosteroid 11-beta-dehydrogenase, isozyme 1 Target Info Inhibitor [535877]
KEGG Pathway Steroid hormone biosynthesis
Metabolism of xenobiotics by cytochrome P450
Metabolic pathways
Chemical carcinogenesis
NetPath Pathway IL1 Signaling Pathway
FSH Signaling Pathway
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
WikiPathways Prostaglandin Synthesis and Regulation
Metabolism of steroid hormones and vitamin D
Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 522793ClinicalTrials.gov (NCT00983086) Effects of Consumption of Orange Juice on Vascular Protection and Immune Function: Clinical Study on the Specific Contribution of Citrus Flavanones. U.S. National Institutes of Health.
Ref 540674(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 408).
Ref 535877A rapid screening assay for inhibitors of 11beta-hydroxysteroid dehydrogenases (11beta-HSD): flavanone selectively inhibits 11beta-HSD1 reductase activity. Mol Cell Endocrinol. 2003 Dec 30;212(1-2):41-9.

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