Drug Information

Drug General Information
Drug ID
D0B4WZ
Former ID
DNC010142
Drug Name
3-Benzyl-3-ethyl-1-phenylazetidine-2,4-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530511]
Structure
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2D MOL

3D MOL
Formula
C18H17NO2
Canonical SMILES
CCC1(C(=O)N(C1=O)C2=CC=CC=C2)CC3=CC=CC=C3
InChI
1S/C18H17NO2/c1-2-18(13-14-9-5-3-6-10-14)16(20)19(17(18)21)15-11-7-4-8-12-15/h3-12H,2,13H2,1H3
InChIKey
FWZVCEYFFJOHOK-UHFFFAOYSA-N
PubChem Compound ID
44626901
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [530511]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 530511J Med Chem. 2010 Jan 14;53(1):241-53.4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.
Ref 530511J Med Chem. 2010 Jan 14;53(1):241-53.4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.

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