Drug General Information
Drug ID	D0B6EU
Former ID	DIB015793
Drug Name	AS-35
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Discontinued in Phase 2	[544897]
Company	Mitsubishi-Tokyo Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Formula	C21H20N6O4
Canonical SMILES	n12c(ncc(c1=O)c1nnn[nH]1)c(ccc2)COc1c(c(c(cc1)C(=O)C)O)<br />CCC
CAS Number	CAS 108427-72-1
PubChem Compound ID	130135
Target and Pathway
Target(s)	Cysteinyl leukotriene receptor 1	Target Info	Modulator	[526815]
	Leukotriene CysLT2 receptor	Target Info	Modulator	[526815]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
	Neuroactive ligand-receptor interaction
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	IL4 Signaling Pathway
	IL3 Signaling PathwayNetPath_16:IL4 Signaling Pathway
	IL3 Signaling Pathway
Pathway Interaction Database	Endothelinsendothelinpathway:Endothelins
Reactome	Leukotriene receptors
	G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
	GPCR downstream signaling
References
Ref 544897	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001439)
Ref 526815	Peptide leukotriene antagonistic activity of AS-35, a new antiallergic drug. Jpn J Pharmacol. 1992 Apr;58(4):347-55.

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