Drug General Information
Drug ID	D0B6TW
Drug Name	Leucovorin Calcium
Synonyms	Leucovorin Calcium; Leucovorin Calcium Preservative Free; Wellcovorin; .
Drug Type	Small molecular drug
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Approved	[551871]
Therapeutic Class	Anticancer Agents
Company	Hospira Inc
Structure		Download 2D MOL
Formula	C20H21CaN7O7
PubChem Compound ID	15150
Target and Pathway
Target(s)	DHFR	Target Info	Modulator
KEGG Pathway	One carbon pool by folate
	Folate biosynthesis
	Metabolic pathways
PANTHER Pathway	Tetrahydrofolate biosynthesis
	Formyltetrahydroformate biosynthesis
Pathway Interaction Database	E2F transcription factor network
PathWhiz Pathway	Folate Metabolism
	Pterine Biosynthesis
Reactome	E2F mediated regulation of DNA replication
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	Metabolism of folate and pterines
	G1/S-Specific Transcription
WikiPathways	Nucleotide Metabolism
	Trans-sulfuration and one carbon metabolism
	Retinoblastoma (RB) in Cancer
	One Carbon Metabolism
	Metabolism of water-soluble vitamins and cofactors
	Metabolism of nitric oxide
	Folate Metabolism
	Fluoropyrimidine Activity
References
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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