Drug Information

Drug General Information
Drug ID
D0B7AH
Former ID
DIB011386
Drug Name
INT-777
Synonyms
TGR5 agonist (oral, metabolic disorder), Intercept
Drug Type
Small molecular drug
Indication Metabolic disorders [ICD9: 270-279; ICD10:E70-E89] Investigative [542059]
Company
Intercept Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL
Formula
C27H46O5
InChI
InChI=1S/C27H46O5/c1-6-17-20-12-16(28)9-10-26(20,4)21-13-22(29)27(5)18(14(2)11-15(3)25(31)32)7-8-19(27)23(21)24(17)30/h14-24,28-30H,6-13H2,1-5H3,(H,31,32)/t14-,15+,16-,17-,18-,19+,20+,21+,22+,23+,24-,26+,27-/m1/s1
InChIKey
NPBCMXATLRCCLF-IRRLEISYSA-N
PubChem Compound ID
45483949
PubChem Substance ID
103700193, 104154560, 120295109, 135358607, 170467349, 178103627, 198944780, 226897226, 252479180
Target and Pathway
Target(s) TGR5 Target Info Agonist [543800]
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
References
Ref 542059(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7048).
Ref 543800(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 37).

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