Drug Information
Drug General Information | |||||
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Drug ID |
D0B8DR
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Former ID |
DIB020415
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Drug Name |
MRS1093
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Synonyms |
3,7-Diethoxy-5-hydroxyflavone; MRS-1093
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
Download2D MOL |
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Formula |
C19H18O5
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InChI |
InChI=1S/C19H18O5/c1-3-22-13-10-14(20)16-15(11-13)24-18(12-8-6-5-7-9-12)19(17(16)21)23-4-2/h5-11,20H,3-4H2,1-2H3
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InChIKey |
ZPEWNDIPSPULBP-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Adenosine A3 receptor | Target Info | Antagonist | [2] | |
Adenosine A1 receptor | Target Info | Antagonist | [2] | ||
Adenosine A2b receptor | Target Info | Antagonist | [2] | ||
KEGG Pathway | cGMP-PKG signaling pathway | ||||
cAMP signaling pathway | |||||
Sphingolipid signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
Morphine addictionhsa04015:Rap1 signaling pathway | |||||
Calcium signaling pathway | |||||
Vascular smooth muscle contraction | |||||
Alcoholism | |||||
NetPath Pathway | TCR Signaling Pathway | ||||
RANKL Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
Pathway Interaction Database | C-MYB transcription factor network | ||||
PathWhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine | ||||
Reactome | Adenosine P1 receptors | ||||
G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors | |||||
G alpha (s) signalling events | |||||
Surfactant metabolism | |||||
WikiPathways | Nucleotide GPCRs | ||||
GPCRs, Class A Rhodopsin-like | |||||
GPCRs, OtherWP80:Nucleotide GPCRs | |||||
GPCR ligand binding | |||||
GPCR downstream signalingWP80:Nucleotide GPCRs | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 399). | ||||
REF 2 | J Med Chem. 1996 Jun 7;39(12):2293-301.Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. | ||||
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