Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0B8YZ
|
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| Former ID |
DNC012877
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| Drug Name |
ELTANOLONE
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| Drug Type |
Small molecular drug
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| Indication | Premenstrual syndrome [ICD10:N94.3] | Discontinued in Phase 3 | [546011] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C21H34O2
|
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| Canonical SMILES |
CC(=O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C
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| InChI |
1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15-,16+,17-,18+,19+,20+,21-/m1/s1
|
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| InChIKey |
AURFZBICLPNKBZ-YZRLXODZSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Gamma-aminobutyric acid receptor subunit alpha-1 | Target Info | Inhibitor | [527511] | |
| Gamma-aminobutyric acid receptor subunit beta-2 | Target Info | Inhibitor | [527511] | ||
| Gamma-aminobutyric acid receptor | Target Info | Inhibitor | [528321] | ||
| Gamma-aminobutyric acid receptor subunit gamma-2 | Target Info | Inhibitor | [527511] | ||
| References | |||||
| Ref 527511 | J Med Chem. 2005 Apr 21;48(8):3051-9.Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)-and (3alpha,5beta)-3-hydroxypregnan-20-one. | ||||
| Ref 528321 | J Med Chem. 2006 Jul 27;49(15):4595-605.Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. | ||||
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