Drug General Information
Drug ID	D0B9OG
Former ID	DIB005977
Drug Name	Adipiplon
Synonyms	GABA modulator (insomnia), Neurogen; NG-2-73
Drug Type	Small molecular drug
Indication	Sleep disorders [ICD9: 307.4, 327, 780.5; ICD10:F51, G47]		Phase 2	[522324]
Company	Neurogen Corporation
Structure		Download 2D MOL 3D MOL
Formula	C18H18FN7
Canonical SMILES	c1n2c(c(c(n1)Cn1c(ncc1)c1c(cccn1)F)CCC)nc(n2)C
CAS Number	CAS 840486-93-3
PubChem Compound ID	11198924
Target and Pathway
Target(s)	Gamma-aminobutyric-acid receptor alpha-3 subunit	Target Info	Modulator	[531560]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 522324	ClinicalTrials.gov (NCT00683436) Efficacy and Safety Study of Adipiplon, Placebo and an Active Control in Primary Insomniacs. U.S. National Institutes of Health.
Ref 531560	Discriminative stimulus properties of GABAA receptor positive allosteric modulators TPA023, ocinaplon and NG2-73 in rats trained to discriminate chlordiazepoxide or zolpidem. Eur J Pharmacol. 2011 Oct 1;668(1-2):190-3.

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