Drug Information

Drug General Information
Drug ID
D0BC2E
Former ID
DAP001391
Drug Name
Hydroxyflutamide
Synonyms
HFT; Hydroxyniphtholide; PC1193; Sch 16423; Hydroxy-flutamide; OH-flutamide; Sch-16423; Alpha, alpha, alpha-trifluoro-2-methyl-4'-nitro-m-lactotoluidide; Alpha,alpha,alpha-Trifluoro-2-methyl-4'-nitro-m-lactotoluidide; 2-Hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide; 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Drug Type
Small molecular drug
Indication Prostate cancer [ICD9: 185; ICD10:C61] Approved [536387], [539887]
Therapeutic Class
Anticancer Agents
Structure
Download
2D MOL

3D MOL
Formula
C11H11F3N2O4
InChI
InChI=1S/C11H11F3N2O4/c1-10(2,18)9(17)15-6-3-4-8(16(19)20)7(5-6)11(12,13)14/h3-5,18H,1-2H3,(H,15,17)
InChIKey
YPQLFJODEKMJEF-UHFFFAOYSA-N
CAS Number
CAS 52806-53-8
PubChem Compound ID
91649
PubChem Substance ID
6098624, 7847014, 7888141, 8027016, 10224937, 14898038, 17388977, 44422573, 48425200, 50020267, 50373625, 53789400, 56314870, 57334991, 71855504, 85856702, 88814879, 93165971, 93580018, 93618743, 95690522, 103119153, 103169927, 103854968, 103919533, 104253499, 104405334, 117362536, 118046573, 124890318, 124890319, 124890320, 125230930, 125371524, 126644703, 126727266, 126729472, 129830005, 134213533, 134338599, 135047620, 135650359, 135692442, 137185104, 137237595, 140728616, 143492980, 144208402, 144213961, 152237015
Target and Pathway
Target(s) Androgen receptor Target Info Antagonist [534842], [535939], [536387]
KEGG Pathway Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 536387Drug insight: role of the androgen receptor in the development and progression of prostate cancer. Nat Clin Pract Oncol. 2007 Apr;4(4):236-44.
Ref 539887(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2862).
Ref 534842Androgen antagonistic effect of estramustine phosphate (EMP) metabolites on wild-type and mutated androgen receptor. Biochem Pharmacol. 1998 May 1;55(9):1427-33.
Ref 535939Ectopic expression of the amino-terminal peptide of androgen receptor leads to androgen receptor dysfunction and inhibition of androgen receptor-mediated prostate cancer growth. Mol Cell Endocrinol. 2004 Feb 12;214(1-2):175-87.
Ref 536387Drug insight: role of the androgen receptor in the development and progression of prostate cancer. Nat Clin Pract Oncol. 2007 Apr;4(4):236-44.

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