Drug Information

Drug General Information
Drug ID
D0BK6B
Former ID
DNC003901
Drug Name
CI-930
Drug Type
Small molecular drug
Indication Discovery agent Discontinued in Phase 2 [544562]
Structure
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2D MOL

3D MOL
Formula
C14H14N4O
Canonical SMILES
CC1CC(=O)NN=C1C2=CC=C(C=C2)N3C=CN=C3
InChI
1S/C14H14N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-7,9-10H,8H2,1H3,(H,16,19)
InChIKey
AEZZPAQOEUQNBB-UHFFFAOYSA-N
PubChem Compound ID
3021729
Target and Pathway
Target(s) CGMP-inhibited 3',5'-cyclic phosphodiesterase A Target Info Inhibitor [533015]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
cAMP signaling pathway
Morphine addiction
Reactome cGMP effects
G alpha (s) signalling events
WikiPathways miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 544562Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000144)
Ref 533015J Med Chem. 1989 Feb;32(2):342-50.Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for the treatment of congestive heart failure.

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