Drug Information

Drug General Information
Drug ID
D0C0AS
Former ID
DNC004424
Drug Name
PD-171729
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534796]
Structure
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2D MOL

3D MOL
Formula
C20H24Cl2N4
Canonical SMILES
CCCCN(CC)C1=CC(=NC2=C(C(=NN12)C)C3=C(C=C(C=C3)Cl)Cl)C
InChI
1S/C20H24Cl2N4/c1-5-7-10-25(6-2)18-11-13(3)23-20-19(14(4)24-26(18)20)16-9-8-15(21)12-17(16)22/h8-9,11-12H,5-7,10H2,1-4H3
InChIKey
DVFPSRARRBNMBH-UHFFFAOYSA-N
PubChem Compound ID
9800614
Target and Pathway
Target(s) Corticotropin releasing factor receptor 1 Target Info Inhibitor [534796]
KEGG Pathway Neuroactive ligand-receptor interaction
Long-term depression
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Cortocotropin releasing factor receptor signaling pathway
Reactome Class B/2 (Secretin family receptors)
G alpha (s) signalling events
WikiPathways GPCRs, Class B Secretin-like
Myometrial Relaxation and Contraction Pathways
Corticotropin-releasing hormone
GPCR ligand binding
GPCR downstream signaling
References
Ref 534796Bioorg Med Chem Lett. 1998 Aug 18;8(16):2067-70.Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists.
Ref 534796Bioorg Med Chem Lett. 1998 Aug 18;8(16):2067-70.Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists.

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