Drug Information

Drug General Information
Drug ID
D0C0HP
Former ID
DIB020049
Drug Name
IN-3
Synonyms
IN 3; analogue 24 [PMID: 11551758]
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526138]
Structure
Download
2D MOL
Formula
C37H46N4O
InChI
InChI=1S/C37H46N4O/c1-24-18-25(2)20-29(19-24)35-34(26(3)22-39-17-14-27-12-15-38-16-13-27)32-21-30(8-11-33(32)40-35)37(4,5)36(42)41-23-28-6-9-31(41)10-7-28/h8,11-13,15-16,18-21,26,28,31,39-40H,6-7,9-10,14,17,22-23H2,1-5H3/t26-,28?,31?/m1/s1
InChIKey
GGVFLXSCFPVLMS-WPCLDFDBSA-N
PubChem Compound ID
10231401
PubChem Substance ID
15232392, 16591575, 22618844, 41004829, 75819393, 103293903, 104000490, 140269861, 178102219, 227735977, 245966145
Target and Pathway
Target(s) Gonadotropin-releasing hormone receptor Target Info Antagonist [526374]
KEGG Pathway Neuroactive ligand-receptor interaction
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Hormone ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 526138Orally bioavailable, indole-based nonpeptide GnRH receptor antagonists with high potency and functional activity. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2597-602.
Ref 526374Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target. JClin Endocrinol Metab. 2002 Jul;87(7):3255-62.

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