Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0C1ZQ
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| Former ID |
DIB015568
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| Drug Name |
Estrogen receptor beta modulators
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| Synonyms |
IDDBCP245397
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| Indication | Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] | Investigative | [1] | ||
| Company |
GlaxoSmithKline plc
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
O=S(=O)(N1C2(CCCCC2)C=C(c2ccccc12)C)c1ccc(cc1)O
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| Target and Pathway | |||||
| Target(s) | Estrogen receptor beta | Target Info | Modulator | [2] | |
| KEGG Pathway | Estrogen signaling pathway | ||||
| Prolactin signaling pathway | |||||
| Pathway Interaction Database | Plasma membrane estrogen receptor signaling | ||||
| Validated nuclear estrogen receptor beta network | |||||
| Validated nuclear estrogen receptor alpha network | |||||
| Reactome | Nuclear Receptor transcription pathway | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Ovarian Infertility Genes | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Nuclear Receptors | |||||
| References | |||||
| REF 1 | A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta. J Med Chem. 2002 Dec 5;45(25):5492-505. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 621). | ||||
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