TTD | Drug: D0C2ET

Drug General Information
Drug ID	D0C2ET
Former ID	DIB016716
Drug Name	(R)-mequitazine (incontinence/respiratory disease), Pierre Fabre
Synonyms	V-0162; Muscarinic M1/M2/M3 antagonist (incontinence/respiratorydisease), Pierre Fabre; (R)-mequitazine
Indication	Respiratory disease [ICD10:J00-J99]		Phase 2	[524448]
Company	Pierre Fabre SA
Structure		Download 2D MOL 3D MOL
Canonical SMILES	[C@H]1([C@@H]2CCN(C1)CC2)CN1c2ccccc2Sc2c1cccc2
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M3	Target Info	Modulator
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Regulation of actin cytoskeleton
	Insulin secretion
	Salivary secretion
	Gastric acid secretion
	Pancreatic secretion
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway	Gastric Acid Production
Reactome	Muscarinic acetylcholine receptors
	Acetylcholine regulates insulin secretion
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 524448	ClinicalTrials.gov (NCT01951222) Bronchodilator Properties and Safety in Asthma. U.S. National Institutes of Health.

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Drug Information