Drug Information

Drug General Information
Drug ID
D0C2QS
Former ID
DIB009168
Drug Name
MEDI-3617
Synonyms
Fully human anti-angiopoietin 2 mAb (cancer), MedImmune
Drug Type
Antibody
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [548917]
Company
Astrazeneca; medimmune
Target and Pathway
Target(s) Angiopoietin-2 Target Info [531798]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
PI3K-Akt signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiogenesis
Pathway Interaction Database Angiopoietin receptor Tie2-mediated signaling
Reactome Tie2 Signaling
WikiPathways Cell surface interactions at the vascular wall
References
Ref 548917Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030291)
Ref 531798MEDI3617, a human anti-angiopoietin 2 monoclonal antibody, inhibits angiogenesis and tumor growth in human tumor xenograft models. Int J Oncol. 2012 May;40(5):1321-30.

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