Drug Information

Drug General Information
Drug ID
D0C5SV
Former ID
DIB018819
Drug Name
alpha-linolenic acid
Synonyms
linolenate; alpha-LA; C18:3
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538632]
Structure
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2D MOL

3D MOL
Formula
C18H30O2
InChI
InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-
InChIKey
DTOSIQBPPRVQHS-PDBXOOCHSA-N
PubChem Compound ID
5280934
PubChem Substance ID
8662, 68740, 819802, 841483, 3139635, 7850017, 7888669, 8144514, 8616449, 10523461, 14750830, 17388945, 24882198, 24882199, 24896311, 26752891, 26752892, 29204335, 29215108, 39289903, 46507620, 47216552, 47588760, 48423612, 48425247, 48496160, 50105513, 50105514, 53787037, 57260459, 57260460, 57299395, 57357935, 57651877, 80135193, 85209429, 85272559, 85787693, 87572018, 92298206, 92309792, 99300706, 99302224, 103167706, 104046526, 104098240, 113854245, 124573768, 124800395, 124890383
Target and Pathway
Target(s) GPR40 Target Info Agonist [526570]
G-protein coupled receptor 120 Target Info Agonist [529354]
KEGG Pathway Insulin secretion
Reactome G alpha (q) signalling events
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
WikiPathways GPCRs, Class A Rhodopsin-like
Incretin Synthesis, Secretion, and Inactivation
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP2728:Incretin Synthesis, Secretion, and Inactivation
References
Ref 538632(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1049).
Ref 526570Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature. 2003 Mar 13;422(6928):173-6. Epub 2003 Feb 23.
Ref 529354Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):515-22.

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