Drug General Information
Drug ID	D0C5YQ
Former ID	DIB004995
Drug Name	SDZ-62-826
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Terminated	[545716]
Company	Novartis AG
Structure		Download 2D MOL 3D MOL
Canonical SMILES	P(=O)([O-])(OCC1CCN(C(=O)OCCCCCCCCCCCCCCCCCC)CC1)OCC[N+<br />](C)(C)C
CAS Number	CAS 108225-40-7
Target and Pathway
Target(s)	Granulocyte-macrophage colony-stimulating factor receptor alpha chain	Target Info	Modulator	[543463]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	Hematopoietic cell lineage
	Pathways in cancer
NetPath Pathway	IL3 Signaling Pathway
	RANKL Signaling Pathway
Pathway Interaction Database	GMCSF-mediated signaling events
	Alpha9 beta1 integrin signaling events
Reactome	GPVI-mediated activation cascade
	G beta:gamma signalling through PI3Kgamma
	Interleukin-3, 5 and GM-CSF signaling
	RAF/MAP kinase cascade
	Surfactant metabolism
	Interleukin receptor SHC signaling
WikiPathways	Interleukin-2 signaling
	Interleukin-3, 5 and GM-CSF signaling
References
Ref 545716	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004355)
Ref 543463	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1707).

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