Drug Information

Drug General Information
Drug ID
D0C9SY
Former ID
DAP000414
Drug Name
Vardenafil
Synonyms
VDN; Levitra (TN); VARDENAFIL, LEVITRA; Vardenafil (INN); 1-((3-(3,4-Dihydro-5-methyl-4-oxo-7-propylimidazo(5,1-f)-as-triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine; 2-(2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl)-5-methyl-7-propyl-3H-imidazo(5,1-f)(1,2,4)triazin-4-one; 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one; 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE; 2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4-ol
Drug Type
Small molecular drug
Indication Erectile dysfunction [ICD9: 302.72, 607.84; ICD10:F52.2, N48.4] Approved [536493], [542344]
Therapeutic Class
Antiimpotence Agents
Company
Bayer Pharmaceuticals Corporation
Structure
Download
2D MOL

3D MOL
Formula
C23H32N6O4S
InChI
InChI=1S/C23H32N6O4S/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30)
InChIKey
SECKRCOLJRRGGV-UHFFFAOYSA-N
CAS Number
CAS 224785-90-4
PubChem Compound ID
110634
PubChem Substance ID
585747, 833312, 7891048, 7980307, 10235224, 14785997, 14932815, 28477354, 44439098, 46506777, 46515101, 48034817, 49737956, 50012454, 50112786, 50365874, 53787736, 60818951, 85789651, 89521986, 92308880, 93342988, 96025351, 99645193, 103558698, 103854631, 104253666, 104386549, 117886401, 124757847, 125164651, 125433166, 126680944, 129223014, 131856665, 134337710, 134358350, 135067955, 135610269, 135692501, 136352775, 136946635, 137002811, 137053214, 142001694, 152134184, 160650107, 160849672, 160964203, 162037977
SuperDrug ATC ID
G04BE09
SuperDrug CAS ID
cas=224785904
Target and Pathway
Target(s) CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Binder [535626]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome cGMP effects
References
Ref 536493Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today. 2007 Sep;12(17-18):757-66. Epub 2007 Aug 27.
Ref 542344(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7320).
Ref 535626The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease. J Am Coll Cardiol. 2002 Dec 4;40(11):2006-12.

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