Drug Information

Drug General Information
Drug ID
D0C9XA
Former ID
DPR000001
Drug Name
GSK683699
Drug Type
Small molecular drug
Indication Crohn's disease; Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51] Phase 2 [536371]
Company
GSK; Tanabe
Structure
Download
2D MOL

3D MOL
Formula
C4H9NO2
Canonical SMILES
C(CC(=O)O)CN
InChI
1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChIKey
BTCSSZJGUNDROE-UHFFFAOYSA-N
PubChem Compound ID
119
PubChem Substance ID
3628, 87901, 90737, 99151, 102735, 588080, 841798, 3131894, 5006226, 7847126, 7885654, 7979337, 8138105, 8138144, 8138251, 8138279, 8139983, 8145275, 8149630, 8150467, 10527343, 11110722, 11113457, 11335791, 11361030, 11362843, 11365405, 11367967, 11372289, 11374436, 11376129, 11462002, 11484732, 11489024, 11491200, 11492624, 11493863, 14818111, 17404570, 24278167, 24424261, 24424263, 24438498, 24701168, 24715057, 24891025, 25623205, 26512225, 26612021, 26679211
Target and Pathway
Target(s) Integrin alpha-4 Target Info Binder [536371]
KEGG Pathway PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cell adhesion molecules (CAMs)
Hematopoietic cell lineage
Leukocyte transendothelial migration
Intestinal immune network for IgA production
Regulation of actin cytoskeleton
Leishmaniasis
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy
PANTHER Pathway Integrin signalling pathway
Pathway Interaction Database Beta1 integrin cell surface interactions
Integrin family cell surface interactions
Arf6 trafficking events
CXCR4-mediated signaling events
Plexin-D1 Signaling
a4b7 Integrin signaling
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
VEGFR3 signaling in lymphatic endothelium
Alpha4 beta1 integrin signaling events
Reactome Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Integrin cell surface interactions
WikiPathways Focal Adhesion
Arrhythmogenic Right Ventricular Cardiomyopathy
Integrin-mediated Cell Adhesion
Integrin cell surface interactions
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
References
Ref 536371Emerging drugs to treat Crohn's disease. Expert Opin Emerg Drugs. 2007 Mar;12(1):49-59.
Ref 536371Emerging drugs to treat Crohn's disease. Expert Opin Emerg Drugs. 2007 Mar;12(1):49-59.

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