Drug Information

Drug General Information
Drug ID
D0CD6I
Former ID
DIB009454
Drug Name
CNTF, Syntex-Synergen, cell therapy
Synonyms
Ciliary neurotrophic factor (human); CNTF, Syntex-Synergen; Cell therapy (neurodegeneration, CRIB); Ciliary neurotrophic factor, Syntex-Synergen; Drug implant (CNTF), CytoTherapeutics; Drug implant (ciliary neurotrophic factor), CytoTherapeutics; RhCNTF, Syntex-Synergen; Cell therapy (neorodegeneration, ECT), CytoTherapeutics; Cell therapy (neurodegeneration, CRIB), CytoTherapeutics
Indication Huntington's disease [ICD9: 294.1, 333.4; ICD10:F02.2, G10] Phase 2 [523794]
Company
Amgen Inc; StemCells Inc
CAS Number
CAS 166870-70-8
Target and Pathway
Target(s) Ciliary neurotrophic factor Target Info Modulator [534370], [534385]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
WikiPathways Differentiation Pathway
References
Ref 523794ClinicalTrials.gov (NCT01530659) Retinal Imaging of Subjects Implanted With Ciliary Neurotrophic Factor (CNTF)-Releasing Encapsulated Cell Implant for Early-stage Retinitis Pigmentosa. U.S. National Institutes of Health.
Ref 534370Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease. Nature. 1997 Mar 27;386(6623):395-9.
Ref 534385Reliability of maximal voluntary isometric contraction testing in a multicenter study of patients with amyotrophic lateral sclerosis. Syntex/Synergen Neuroscience Joint Venture rhCNTF ALS Study Group. Muscle Nerve. 1997 Jun;20(6):691-5.

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