Drug Information

Drug General Information
Drug ID
D0CF0Y
Former ID
DNCL002778
Drug Name
Rolapitant
Drug Type
Small molecular drug
Indication Chemotherapy-induced nausea [ICD9: 787, 787.0; ICD10:R11] Approved [523745], [541084]
Company
TESARO
Structure
Download
2D MOL
Formula
C25H26F6N2O2
InChI
InChI=1S/C25H26F6N2O2/c1-16(17-11-19(24(26,27)28)13-20(12-17)25(29,30)31)35-15-23(18-5-3-2-4-6-18)10-9-22(14-32-23)8-7-21(34)33-22/h2-6,11-13,16,32H,7-10,14-15H2,1H3,(H,33,34)/t16-,22-,23-/m1/s1
InChIKey
FIVSJYGQAIEMOC-ZGNKEGEESA-N
PubChem Compound ID
10311306
PubChem Substance ID
15319052, 22683464, 41377143, 80733074, 135313150, 137150074, 137678628, 170504333, 178102375, 180371716, 184816413, 198955660, 226688142, 248972540, 251910671
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [532860]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 523745ClinicalTrials.gov (NCT01500213) A Safety and Efficacy Study of Rolapitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Subjects Receiving Highly Emetogenic Chemotherapy. U.S. National Institutes of Health.
Ref 541084(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5749).
Ref 532860Netupitant and palonosetron trigger NK1 receptor internalization in NG108-15 cells. Exp Brain Res. 2014 Aug;232(8):2637-44.

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