Drug General Information
Drug ID	D0CG0G
Former ID	DIB008924
Drug Name	11beta-hydroxysteroid dehydrogenase-1 (HSD1) inhibitors
Synonyms	11beta-HSD1 inhibitors (metabolic disorders), Merck
Indication	Atherosclerosis [ICD9: 414.0, 440; ICD10:I70]		Investigative	[552025]
Company	Merck & Co Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	O=S(=O)(CC[C@]12CC[C@](c3n(c(nn3)c3ccccc3C(F)(F)F)C)(CC<br />1)CC2)CC
Target and Pathway
Target(s)	Corticosteroid 11-beta-dehydrogenase, isozyme 1	Target Info	Inhibitor	[543704]
KEGG Pathway	Steroid hormone biosynthesis
	Metabolism of xenobiotics by cytochrome P450
	Metabolic pathways
	Chemical carcinogenesis
NetPath Pathway	IL1 Signaling Pathway
	FSH Signaling Pathway
PathWhiz Pathway	Steroidogenesis
Reactome	Glucocorticoid biosynthesis
WikiPathways	Prostaglandin Synthesis and Regulation
	Metabolism of steroid hormones and vitamin D
	Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 552025	High-throughput screening of 11beta-hydroxysteroid dehydrogenase type 1 in scintillation proximity assay format. Assay Drug Dev Technol. 2005 Aug;3(4):377-84.
Ref 543704	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2763).

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